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  • Writer's pictureNicholas Murtha

Nutritional risk in major abdominal surgery: NURIMAS Liver - protocol of a prospective obser...

Nutritional risk in major abdominal surgery: NURIMAS Liver (DRKS00010923) - protocol of a prospective observational trial to evaluate the prognostic value of different nutritional scores in hepatic surgery

Pascal Probst, Juri Fuchs, Michael R Schoen, Georgios Polychronidis, Tobias Forster, Arianeb Mehrabi, Alexis Ulrich, Philipp Knebel, Katrin Hoffmann

PMID: 31851731 PMCID: PMC6913555 DOI: 10.1016/j.isjp.2017.09.001


Background: Malnutrition is commonly known as a risk factor in surgical procedures. The nutritional status seems particularly relevant to the clinical outcome of patients undergoing hepatic resection. Thus, identifying affected individuals and taking preventive therapeutic actions before surgery is an important task. However, there are only very few studies, that investigate which existing nutritional assessment score (NAS) is suited best to predict the postoperative outcome in liver surgery.

Objective: Nutritional Risk in Major Abdominal Surgery (NURIMAS) Liver is a prospective observational trial that analyses the predictive value of 12 different NAS for postoperative morbidity and mortality after liver resection.

Methods: After admission to the surgical department of the University Hospital in Heidelberg or the municipal hospital of Karlsruhe, all patients scheduled for elective liver resection will be screened for eligibility. Participants will fill in a questionnaire and undergo a physical examination in order to evaluate nutritional status according to Nutritional Risk Index, Nutritional Risk Screening Score, Subjective Global Assessment, Malnutrition Universal Screening Tool, Mini Nutritional Assessment, Short Nutritional Assessment Questionnaire, Imperial Nutritional Screening System, Imperial Nutritional Screening System II, Nutritional Risk Classification and the ESPEN malnutrition criteria. Postoperative morbidity and mortality will be tracked prospectively throughout the postoperative course. The association of malnutrition according to each score and occurrence of at least one major complication will be analysed using both chi-squared tests and a multivariable logistic regression analysis. Already established risk factors in liver surgery will be added as covariates.

Discussion: NURIMAS Liver is a bicentric, prospective observational trial. The aim of this study is to investigate the predictive value of clinical nutritional assessment scores on postoperative morbidity and mortality after hepatic resection. This is necessary, as only a validated identification of malnourished patients at high risk for postoperative complications, enables targeted preventive action.

Keywords: Hepatic resection; Liver resection; Liver surgery; Malnutrition; NAS, nutritional assessment score; Nutritional assessment; Nutritional score; PLF, postresectional liver failure; POD, postoperative day.

Int J Surg Protoc. 2017 Sep 9;6:5-10. doi: 10.1016/j.isjp.2017.09.001. eCollection 2017.

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