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  • Writer's pictureNicholas Murtha

Markers of liver regeneration-the role of growth factors and cytokines: a systematic review

Katrin Hoffmann, Alexander Johannes Nagel, Kazukata Tanabe, Juri Fuchs, Karolin Dehlke, Omid Ghamarnejad, Anastasia Lemekhova, Arianeb Mehrabi

PMID: 32050952 PMCID: PMC7017496 DOI: 10.1186/s12893-019-0664-8


Background: Post-hepatectomy liver failure contributes significantly to postoperative mortality after liver resection. The prediction of the individual risk for liver failure is challenging. This review aimed to provide an overview of cytokine and growth factor triggered signaling pathways involved in liver regeneration after resection.

Methods: MEDLINE and Cochrane databases were searched without language restrictions for articles from the time of inception of the databases till March 2019. All studies with comparative data on the effect of cytokines and growth factors on liver regeneration in animals and humans were included.

Results: Overall 3.353 articles comprising 40 studies involving 1.498 patients and 101 animal studies were identified and met the inclusion criteria. All included trials on humans were retrospective cohort/observational studies. There was substantial heterogeneity across all included studies with respect to the analyzed cytokines and growth factors and the described endpoints.

Conclusion: High-level evidence on serial measurements of growth factors and cytokines in blood samples used to predict liver regeneration after resection is still lacking. To address the heterogeneity of patients and potential markers, high throughput serial analyses may offer a method to predict an individual's regenerative potential in the future.

Keywords: Biochemical markers; Cytokines; Growth factors; Liver regeneration; Post-hepatectomy liver failure.

Publication: BMC Surg. 2020 Feb 12;20(1):31. doi: 10.1186/s12893-019-0664-8

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